ParkinsonV1, Main, Exploration, bibRecord, 001748

Limitations of current Parkinson's disease therapy

Identifieur interne : 001748 ( Main/Exploration ); précédent : 001747; suivant : 001749

Limitations of current Parkinson's disease therapy

Auteurs : Olivier Rascol [France] ; Pierre Payoux ; Fabienne Ory ; Joaquim J. Ferreira [Portugal] ; Christine Brefel-Courbon ; Jean-Louis Montastruc

Source :

Annals of Neurology [ 0364-5134 ] ; 2003.

RBID : ISTEX:8375DC24A4BC4E9A05F5C375BBB7AB996C46D84E

Abstract

Levodopa and other dopaminergic medications drastically improve the motor symptoms and quality of life of patients with Parkinson's disease in the early stages of the disease. However, once the “honeymoon” period has waned, usually after a few years of dopaminergic therapy, patients become progressively more disabled despite an ever more complex combination of available antiparkinsonian treatments. Sooner or later, they suffer from “dopa‐resistant” motor symptoms (speech impairment, abnormal posture, gait and balance problems), “dopa‐resistant” nonmotor signs (autonomic dysfunction, mood and cognitive impairment, sleep problems, pain) and/or drug‐related side effects (especially psychosis, motor fluctuations, and dyskinesias). Therefore, the current antiparkinsonian therapy cannot be considered as ideal with regard to both efficacy and safety. Ann Neurol 2003;53 (suppl 3):S3–S15

Url:

https://api.istex.fr/document/8375DC24A4BC4E9A05F5C375BBB7AB996C46D84E/fulltext/pdf

DOI: 10.1002/ana.10513

Affiliations:

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Le document en format XML

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<front><div type="abstract" xml:lang="en">Levodopa and other dopaminergic medications drastically improve the motor symptoms and quality of life of patients with Parkinson's disease in the early stages of the disease. However, once the “honeymoon” period has waned, usually after a few years of dopaminergic therapy, patients become progressively more disabled despite an ever more complex combination of available antiparkinsonian treatments. Sooner or later, they suffer from “dopa‐resistant” motor symptoms (speech impairment, abnormal posture, gait and balance problems), “dopa‐resistant” nonmotor signs (autonomic dysfunction, mood and cognitive impairment, sleep problems, pain) and/or drug‐related side effects (especially psychosis, motor fluctuations, and dyskinesias). Therefore, the current antiparkinsonian therapy cannot be considered as ideal with regard to both efficacy and safety. Ann Neurol 2003;53 (suppl 3):S3–S15</div>
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Limitations of current Parkinson's disease therapy

Limitations of current Parkinson's disease therapy

Source :

Abstract

Links toward previous steps (curation, corpus...)

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Pour manipuler ce document sous Unix (Dilib)

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